Plenarvortrag III: Schwerionen-Therapie
Prof. Dr. Oliver Jäkel
Heidelberger Ionenstrahl-Therapiezentrum am Heidelberger Universitätsklinikum
und Abteilung Medizinische Physik in der Radioonkologie, Deutsches Krebsforschungszentrum, Heidelberg
Sitzungsleiter: Björn Poppe
RADIOTHERAPY WITH HEAVY ION BEAMS
Carbon ions offer a number of potential advantages over conventional radiation and also protons. Most important is their increased energy loss in the Bragg peak region, which gives rise to an enhanced biological effectiveness in the target vs. the surrounding healthy tissue. In vitro studies also demonstrated a reduced oxygen effect, which should allow increased efficiency in the treatment of hypoxic tumours. Moreover, heavy ions suffer less from lateral scattering than protons and induce an activation of irradiated tissues, which allows an in vivo monitoring of the applied dose in the patient by using positron emission tomography. Heavy Radiotherapy with heavy ion beams was first investigated by the pioneering work at the University of California in Berkeley in 1977. Since then, the interest in carbon ion therapy has increased enormously especially in Japan and Europe. There are currently 3 facilities treating patients with carbon ions: two in Japan within a clinical setting and a research facility in Germany, at the Gesellschaft für Schwerionenforschung (GSI). A new hospital based facility at the Heidelberg University will start clinical operation towards the end of 2008 and there are 6 more clinical facilities scheduled to start operation within the next 5 years in Marburg, Pavia (Italy), Gunma (Japan), Kiel, Wiener Neustadt (Austria) and Lyon (France).
The Heidelberg facility is currently in its commissioning phase. It features three treatment rooms and an experimental area, all equipped with active beam scanning systems. One of the treatment rooms is equipped with the first isocentric gantry for ions. The facility is offering beams of protons, helium, oxygen and carbon ions which will be used to evaluate the clinical potential of high LET radiation as compared to low LET radiation. This has important implications for medical physics aspects in treatment planning, dosimetry and quality assurance.
An outline of the current status of heavy ion radiotherapy is given with an emphasis to the clinical rationale for ion beams in radiotherapy, clinical results gained at GSI and technical aspects and status of the new Heidelberg ion beam facility. An outlook on the research programs in the field of heavy ion radiotherapy in Heidelberg will also be given.
Radiation Therapy With Charged Particles
Daniela Schulz-Ertner, Oliver Jäkel, and Wolfgang Schlegel